TDAAC is housed within a 1,400 ft2 laboratory space located in VCU’s Sanger Hall and 799 ft2 laboratory space in Goodwin Research Laboratory Building. TDAAC uses Good Laboratory Practices (GLP) standards to operate and incorporates the best practice guidelines for biorepositories issued by the International Society for Biological and Environmental Repositories and the National Cancer Institute. TDAAC also has access to the 6,400 ft2 Molecular Diagnostics (MDx) CLIA ’88-certified laboratory located in the VCU Department of Pathology. The MDx laboratory performs clinical and research molecular testing with state-of-the-art instrumentation.
Leica BOND RX Automated Research Stainer
- Located in Massey 1-108
- Fully automate tests including IHC, Multiplex Immunofluorescence, Multiplex In Situ Hybridization
- Customize all molecular protocol segments
- Preparation - Customize baking and dewax options
- Antigen Retrieval - Change Incubation time and temperature as desired
- ISH Probes – Leverage new probe application and removal options
- Staining – Choose incubation times, temperatures, dispense types, and more
Lunaphore COMET (coming June 2025)
- Located in Massey 1-132
- Perform a 20-plex on cohorts of 20 samples in just 1 week.
- Slide in, OME-TIFF image out (with background already subtracted).
- Use standard, off-the-shelf, label-free primary antibodies. No conjugation or barcoding needed.
- Tissue morphology and epitope stability are fully preserved for downstream applications.
- Avoid undesired variability thanks to no upstream antibody conjugations.
Akoya Biosciences PhenoImager HT Quantitative Pathology Imager
- Located in Massey 1-108
- State of the art multispectral imaging with onboard spectral unmixing enables the identification and quantification of multiple overlapping biomarkers (up to 6) without the interference of autofluorescence and signal cross-talk
- Renowned liquid crystal tunable filter (LCTF) technology generates unmixed, annotated regions of interest of up to 9-colors for deeper interrogation of biology
- Generate whole slide scans of up to 7 colors in less than 12 minutes (15mm x 15mm region) for analysis of biology across the entire slide in a streamlined workflow and without selection bias
- Fully automated, high-throughput system to accelerate your research and maximize your lab’s resources
- High speed digital whole-slide scanning at 10X-40X in brightfield or fluorescence
- Enclosed system with built-in touchless automation allows you to visualize, analyze, quantify and phenotype immune cells in situ with enhanced security and reliability
- Integrated inForm and phenoptr tissue analysis software packages support configurable projects for biomarker quantification and spatial analysis
3DHISTECH TMA Grand Master with PCR
- Located in Sanger Hall B1-046
- Automates the selection, coring, and placement of tissue samples
- Can process up to 72 recipient blocks and 600 donor blocks in a single run
- Maximum cores / TMA block:
- 0.6mm Cores: 558
- 1.0mm Cores: 286
- 1.5mm Cores: 135
- 2.0mm Cores: 84
- Automated donor block image recording for precise tissue selection
- Digital slide integration: supports MRXS and JPEG formats
- Can extract cores from FFPE blocks for PCR analysis: 60 cores / run
Agilent Automated H&E Staining Dako CoverStainer
- Located in Massey 1-112
- Dako CoverStainer automates every step of the H&E process from baking, dewaxing, and staining through to the dehydrated, coverslipped, and dried slide that is ready for examination. Dako Reagent Management System (DakoRMS), which is an integral part of Dako CoverStainer, automates the reagent handling process, and secures consistent high staining quality as well as better safety for laboratory personnel when handling reagents.
Sakura Tissue-Tek Vacuum Infiltration Processor
Tissue Embedding Console system (TEC)
4 Leica Histocore Biocut microtomes
1 Microm HM-310 microtome
- Located in Sanger Hall B1-046
Leica CM1850 Cryostat
- Located in Sanger Hall B1-046
4 Thermo Scientific PLUS Ultralow Temperature Freezers
- Located in Sanger Hall B1-046
3 Thermo Scientific Locator 4 PLUS Cryobiological Storage Vessels
- Located in Sanger Hall B1-046
HemaVet Multi-Species Hematology Analyzer