Transgenic/Knockout Mouse

About the Transgenic/Knockout Mouse Shared Resource (TGKO)

Genetically engineered mouse models (GEMMs) have become indispensable tools in nearly all fields of biomedical research.  For example, in cancer research their utility ranges from studies of the basic biology of tumorigenesis and progression to the creation of genetically accurate tumor models for the evaluation of novel therapeutic approaches. The objectives of TGKO are to:

  1. Facilitate the development of new GEMMs (including transgenic, knockout, conditional knockout and knock-in mice) using both conventional and CRISPR/Cas9-based technologies
  2. Provide a full range of support services to facilitate the use of these models, including breeding colony management, mouse line rederivation, embryo and sperm cryopreservation and cryorecovery
  3. Offer expert consultation on the development and use of GEMMs

Acknowledge the Transgenic Knock-Out Mouse Shared Resource

All publications that include results, services or products generated by the VCU Massey Comprehensive Cancer Center Shared Resources must include the following acknowledgement in the manuscript:

"Services in support of the research project were provided by the VCU Massey Comprehensive Cancer Center Transgenic/Knockout Mouse Shared Resource, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059."

PubMed Central (PMC) ID numbers are required for those publications that use CCSG-supported shared resources. All of VCU Massey Comprehensive Cancer Center's Shared Resources are supported by the CCSG.

Office of the Vice President for Research and Innovation

This Shared Resource is jointly supported by VCU Massey Comprehensive Cancer Center and the Office of the Vice President for Research and Innovation.