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Cancer Mouse Models Core

Mission

The Cancer Mouse Models Core (CMMC) aspires to make translational research an attainable goal for all Massey researchers. The CMMC provides expertise and services that facilitate preclinical mouse models to support the development of novel cancer therapeutics and precision medicine.

The CMMC works collaboratively with other Massey shared resources, providing assistance with mouse models by using a variety of drug delivery methods, surgical techniques, and animal procedures. The shared resource also offers support with several different types of mouse models: syngeneic models, genetically engineered mice, and xenograft models. The CMMC combines knowledge of preclinical drug testing and cancer mouse models to design and perform experiments that produce accurate data.  

Acknowledge the Cancer Mouse Models Shared Resource

All publications that include results, services or products generated by VCU Massey Cancer Center Shared Resources must include the following acknowledgement in the manuscript:

"Services and products in support of the research project were generated by the Virginia Commonwealth University Cancer Mouse Models Core Laboratory, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059."

PubMed Central (PMC) ID numbers are required for those publications that use CCSG-supported shared resources. All of Massey Cancer Center's Shared Resources are supported by the CCSG.

Suggested grant language

The VCU Cancer Mouse Models Core Laboratory (CMMCL) facilitates in vivo translational research by providing assistance with mouse models of cancer and in vivo drug testing as well as pathology services. Directed by Jennifer Koblinski, PhD, the core employs the core additionally employs a full time lab manager and 2.25 FTE experienced in designing and performing experiments using syngeneic, xenograft [including patient-derived xenograft (PDX)], and genetically engineered mouse models of primary and metastatic cancer. CMMCL staff members provide experiment consultation and train researchers in specific animal procedures. Additionally, the CMMCL provides histology services including H&E staining, IHC, ISH and OPAL staining. We have an Akoya Biosciences, Vectra Polaris and Infrom software, which allows for automated quantitative pathology imaging. The facility is equipped with: a cell culture and preparation room that includes a BSL2 cell culture hood, Zeiss Axio Zoom V16 fluorescence dissection microscope, and BioRad TC20 automatic desktop cell counter; a KOPF 963SD Neurostar Motorized Ultra Precise Small Animal Stereotaxic Instrument for precise delivery of drug or tumor cells; an IVIS Spectrum preclinical in vivo imaging system; Coloview for endoscopy of small animals; Hemavet for Complete Blood Count, and data management and analysis tools that include StudyLog Desktop software, Living Image 4.5.1 software, ImageJ software, and access to the MCC shared research drive. The CMMCL is located on the first floor of the Massey Cancer Center Goodwin Research Laboratories in rooms MCC 1-112 (histology) and MCC 1-108 (mouse models). The facility is supported, in part, by funding from the NIH-NCI Cancer Center Support Grant P30 CA 016059.

Office of the Vice President for Research and Innovation

This Shared Resource is jointly supported by VCU Massey Cancer Center and the Office of the Vice President for Research and Innovation.