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Can Senkal, Ph.D.

  • Program Cancer Biology
  • Department
    Assistant Professor, Department of Biochemistry and Molecular Biology, School of Medicine
  • Phone 804-828-2620
 
Department affiliations
Assistant Professor, Department of Biochemistry and Molecular Biology, School of Medicine
Education
PhD, The Medical University of South Carolina, 2008
Disease focus of research

Breast, Colorectal, Pancreatic, Respiratory/lung

Research keywords

Apoptosis,Autophagy,Cancer cell biology,Cancer therapy,Cell signaling,Lipid signaling,Metabolism,Obesity,Oncogenes,Proteomics,Signal transduction

Research description
We study the metabolism, regulation, and biological functions of sphingolipids in cancer. We focus on cancer biologies, such as mitophagy/lethal autophagy, tumor initiation, response to therapy, and metastasis. We want to identify how ceramide generation by ceramide synthase enzymes is regulated in cancer versus in normal cells. More specifically, we are trying to answer the following questions: What are the roles of SL metabolism in cancer? How does ceramide exert its anti-cancer effects? How can ceramide/sphingolipids regulate signaling pathways? How are the sphingolipid metabolic enzymes regulated in cancer versus normal states? How can ceramides with different fatty acyl chains can have distinct roles, modulating different biologies? To answer these questions, we use several biochemical, genetic, and pharmacological approaches that complement each other.
Published research (during tenure as a Massey Cancer Center member)
Contact information

Email: can.senkal@vcuhealth.org